A Universal Culture Medium for Screening Polymyxin-Resistant Gram-Negative Isolates
نویسندگان
چکیده
منابع مشابه
A Universal Culture Medium for Screening Polymyxin-Resistant Gram-Negative Isolates.
The colistin-containing SuperPolymyxin medium was developed for screening polymyxin-resistant Gram-negative bacteria. It was evaluated with 88 polymyxin-susceptible or polymyxin-resistant cultured Gram-negative isolates. Its sensitivity and specificity of detection were ca. 100%. The SuperPolymyxin medium is the first screening medium that is able to detect intrinsic and acquired polymyxin-resi...
متن کاملOptimizing Polymyxin Combinations Against Resistant Gram-Negative Bacteria
Polymyxin combination therapy is increasingly used clinically. However, systematic investigations of such combinations are a relatively recent phenomenon. The emerging pharmacodynamic (PD) and pharmacokinetic (PK) data on CMS/colistin and polymyxin B suggest that caution is required with monotherapy. Given this situation, polymyxin combination therapy has been suggested as a possible way to inc...
متن کاملCHROMagar COL-APSE: a selective bacterial culture medium for the isolation and differentiation of colistin-resistant Gram-negative pathogens.
PURPOSE A selective chromogenic culture medium for the laboratory isolation and differentiation of colistin resistant Acinetobacter, Pseudomonas, Stenotrophomonas and Enterobacteriaceae spp. (CHROMagar COL-APSE) was developed, evaluated and compared to an existing selective bacterial culture medium (SuperPolymyxin). METHODOLOGY The medium was challenged with 84 isolates, including polymyxin B...
متن کاملPolymyxin-resistant clinical isolates of Escherichia coli.
A surveillance study to identify patients from the community with Escherichia coli resistant to broad-spectrum cephalosporins discovered two isolates that were also resistant to polymyxin B and colistin. One isolate from a patient in the community and a second from a patient who received multiple courses of polymyxin B also possessed a CTX-M-15 enzyme. Resistance to cationic peptides in E. coli...
متن کاملSafety and efficacy of polymyxin B in multidrug resistant Gram-negative severe sepsis and septic shock
BACKGROUND AND AIMS The emergence of multidrug resistant strains of Gram-negative bacteria, especially the lactose nonfermenters like Pseudomonas and Acinetobacter, in the intensive care units have prompted renewed worldwide interest in the polymyxins. However, perceived nephrotoxicity has been a major vexation limiting their early and regular use in severe sepsis. This study was conducted to a...
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ژورنال
عنوان ژورنال: Journal of Clinical Microbiology
سال: 2016
ISSN: 0095-1137,1098-660X
DOI: 10.1128/jcm.00446-16